Best Alpha Lipoic Acid Supplements Reviews & Ratings

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In a Hurry? Editors choice:
1. Doctor's Best
Test Winner: 1. Doctor's Best
Last Updated: February 03, 2020
By Briana Bennett:

These incredibly important fatty acids deserve a lot more awareness. We’ve updated and revised the supplements on this list so you can pick the one best suited to you. All-inclusive, Doctor’s Best is still the best (pun intended) lipoic acid on this list – but the others still offer more than a bang for your buck and may be better well-suited to those of you with special dietary requirements. Read about benefits, possible side effects and dosage requirements galore in this article.

Alpha Lipoic Acid (ALA) is a type of fatty acid that is found in mitochondria. It plays a great role in energy metabolism and in decreasing blood glucose level. It functions as an antioxidant by reducing oxidation as a result of increasing antioxidant enzymes. It is also known as lipoic acid or thioctic acid.

Alpha Lipoic Acid is naturally synthesized in the body but not in sufficient amounts. We can obtain it from food, especially meat from organ tissues. It is also in small quantities in some fruits and vegetables.

Doctor's Best
  • Doctor's Best
  • 5 out of 5
    Our rating
  • Good Results
  • Price: See Here
Superior Labs
  • Superior Labs
  • 4.6 out of 5
    Our rating
  • Purity
  • Price: See Here
Nutricost
  • Nutricost
  • 4.3 out of 5
    Our rating
  • Affordable
  • Price: See Here

Use of Alpha Lipoic Acid commenced between the 1930s and 1950s when scientists isolated it from a potato growth factor. The scientists involved realized that the factor was essential in the growth of a certain bacteria. It is in later years that it was discovered that Alpha Lipoic Acid is an antioxidant and that it plays a role in Kreb’s Cycle. This cycle is a series of chemical reactions in aerobic metabolism that leads to release of stored energy from carbs, fats, and proteins.

Today, it is marketed as an antioxidant and is licensed in Germany to be used as a treatment for diabetic neuropathy.

R-alpha-Lipoic Acid (R-ALA) and S-alpha Lipoic Acid (S-ALA)

Alpha-lipoic Acid nutritional supplements are typically sold as either R-ALA alone or as a mixture of S-ALA and R-ALA. The naturally occurring form of Alpha Lipoic Acid is the R- type while the S- is the is a synthetic form. Most of the products that you will find in the market are a mixture of both. The two forms have different biological activities and questions arise on which one is better than the other. We cannot pin that one is more effective than the other, but most of the previous scientific studies were done using the S form since it’s the one that was more readily available.

The natural form is responsible for most of the benefits especially the role of co-functioning for mitochondrial regulation of energy production. However, when the R form is separated from the S form, it tends to be physically unstable, and when stored in a place above room temperature, it weakens to an insoluble compound. That is the reason that most products have combined the two forms and if the R form is alone, it must be stabilized.

10 Best Alpha Lipoic Acid Supplements

1. Doctor's Best

1. Doctor's Best
Doctors Best's supplement is in the bio-enhanced form which is more stabilized, absorbed better and is not prone to degradation at high temperatures. It is stabilized with sodium which is less than 1% of the recommended value, so there is no cause for alarm about high sodium intake. It is also combined with D-biotin, a water-soluble vitamin that helps in the utilization of vitamin B complexes and absorption of Alpha lipoic acid. It comes in powder form and encapsulated with a vegetable sourced capsule. The caps are non-GMO, free of gluten and soy, and ideal for vegetarians.
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Features/Specifications

  • Has 600mg of Alpha Lipoic Acid
  • Other ingredients include modified microcrystalline cellulose, silicon dioxide, magnesium silicate, and magnesium stearate (vegetable source)
  • Non-GMO
  • Free of gluten and soy
  • Suitable for a vegan diet
  • Each bottle has 60 capsules

Directions for use:

Take one to two capsules daily or as advised by a physician. Preferably, should be taken in between meals.

Price/Value

Doctor’s Best product is reasonably priced considering that it has tablets that can last you for up to two months and also, that it is a natural product that is more readily absorbed and more stable than others.

Verdict

Doctor’s Best supplements are not only well-priced but also do what they are meant to do. From the user reviews and clinical studies done, the results of the tablets are clearly evident if used alongside other medications prescribed by a physician or a nutritionist. Moreover, they are easily absorbed by the body and have fewer side effects.

Pros
  • Is a powder in a capsule, so can be added to food or fluids
  • Results are seen within a short period of use
  • Minimal side effects
  • Easily absorbed from the digestive tract
Cons
  • Causes a burning sensation
  • Powder form easily solidifies

2. Superior Labs

2. Superior Labs
These supplements are made in the USA in an FDA approved facility under GMP standards. They come in capsule form, with a therapeutic dose of 600mg. There are no artificial additives, and the only other inactive ingredients are the vegetable capsule and natural rice flour. On quality, this product has undergone third-party testing and independent tests of heavy metals and other pollutants.
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Features/Specifications

  • Has 600mg of Alpha Lipoic Acid
  • Inactive ingredients are vegetable capsule and natural rice flour
  • GMP and FDA compliant
  • Has undergone third-party tests for quality
  • Free of artificial additives
  • Non-GMO
  • Each bottle has 120 vegetable capsules

Directions for use:

for adults, take one tablet daily. If you experience any abdominal discomfort, take the capsules together with food.

Price/Value

These are slightly in the higher price range, but it would be prudent to consider that each package has a supply of about four months. Also, consider that the quality of these tablets is unquestionable as they have undergone third-party testing.

Verdict

The supplements are superior to the rest due to their quality. They may need you to spend a little more, but you will have peace of mind knowing that you are buying a product that is safe and made in approved facilities. Furthermore, each bottle has 120 tablets which are more than most other products.

Pros
  • Has undergone independent purity tests
  • Capsules are pure with no artificial additives
  • Suitable for a vegetarian diet
  • Effects seen within a short time
  • Effective for neuropathic pain
  • Quality is uncompromised
Cons
  • Has a strong odor

3. Nutricost

3. Nutricost
Nutricost capsules come in smaller doses of 300mg, but you need two per serving to make a total of 600mg. It is a USA-made product that is non-GMO, gluten-free and of high quality. The Alpha Lipoic Acid is in capsule form. Other than the active ingredient, it has gelatin, rice flour, calcium silicate, silicon dioxide and magnesium stearate.
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Features/Specifications

  • Made in the USA
  • Each capsule is 300mg of Alpha Lipoic Acid
  • Non-GMO
  • Gluten free
  • Inactive ingredients include gelatin, rice flour, calcium silicate, silicon dioxide, and magnesium stearate
  • Each bottle has 240 capsules fit for 120 servings

Directions for use:

take two capsules one to two times daily with food. Should only be taken by adults.

Price/Value

The product is very affordable considering that it comes as a package of 240 capsules that are 120 servings. This quantity can last you for about four months if you are taking the minimum dosage, which is what is recommended.

Verdict

These are effective and yet very affordable. From the user reviews, it is undoubted that this product does what it is supposed to, especially in dealing with neuropathic pain. You may experience some abdominal discomfort when taking it, but this can be avoided by taking the supplements with food.

Pros
  • Has many tablets
  • Affordable and effective
  • Non-GMO
  • High quality
  • Free of gluten
Cons
  • Large tablets

4. Dr. Danielle

4. Dr. Danielle
Dr. Danielle Alpha Lipoic Acid is in R-ALA form which is more superior, stable and absorbed better. Each capsule has R-Alpha type in 300mg and S-Alpha type in 250mg. The combination of the two types makes it easier to absorb, metabolize and utilize. The capsules are sourced from natural products and are suitable for vegetarians.
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Features/Specifications

  • Contains both R-Alpha Lipoic Acid and S-Alpha Lipoic Acid
  • Available as a vegetable capsule
  • Suitable for vegetarians
  • No artificial additives
  • The only inactive ingredient is the vegetable capsule
  • Each package has 120 capsules

Directions for use:

take one capsule daily or as directed by a healthcare provider

Price/Value

Dr. Danielle’s supplement is in the higher price range. However, it is worth buying considering that product is pure Alpha Lipoic Acid with no fillers, binders or artificial additives. In addition, it contains both S and R forms, making it very easy to absorb and metabolize.

Verdict

This product may be pricey, but its quality speaks volume. It is a pure form that is in both the S and R forms. It has minimal side effects since it has no artificial additives. It is a great value product that is worth your money.

Pros
  • Contains both S and R form of Lipoic acid
  • Easily absorbed and effective
  • Small easy to swallow capsules
  • No artificial additives
  • Suitable for vegetarians
  • No fillers and binders
Cons
  • Pricey

5. Pure Encapsulations

5. Pure Encapsulations
Pure Encapsulations's product stands out as it comes in smaller doses of 200mg, thus filling in the gap for those who need a lesser strength. The tablets are obtained from natural plant sources thus suitable for vegans and vegetarians. They are free of gluten, artificial additives and are hypoallergenic. On quality, the tablets have been subjected to independent purity and potency tests.
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Features/Specifications

  • Are in tablet form
  • Each tablet is 200mg
  • Active ingredient is Alpha Lipoic Acid
  • Inactive ingredients include hypoallergenic plant fiber (cellulose), ascorbyl palmitate, vegetarian capsule (cellulose)
  • Each bottle has 60 tablets

Recommended dose:

take 1 to 4 tablets per day, preferably with meals

Price/Value

This option is quite pricey, but it is worth considering if you want or you have a prescription in low dosage. A lot of work has also gone into ensuring that it is a pure product that is hypoallergenic and has no artificial additives.

Verdict

Thesetablets may cost you more, but you will be sure that you are taking a product that is safe, pure and has minimal side effects. Sometimes you have to spend more to get quality, and in most instances, a lot of expenses have gone into delivering an effective and safe product.

Pros
  • Has a smaller dose
  • Hypoallergenic
  • Suitable for vegetarians
  • No added fillers
  • Easy to swallow
Cons
  • Pricey

6. Jarrow Formulas

6. Jarrow Formulas
Jarrow Formulas manufacturer has been on the market for a very long time and has been producing other quality nutritional supplements. It is a strong brand with an excellent longstanding reputation. Their Alpha Lipoic Acid is no exception as it is in the R-form which is easily metabolized and utilized by the body. Each of their tablets is the minimal dose of 100mg of R-form and 150mg of d-Biotin. The tablets are free of most potential allergens, are suitable for vegetarian and vegan diets, and are in capsule form.
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Features/Specifications

  • Contains both R-ALA and d-biotin
  • Is in capsule form
  • Active ingredients are R-Alpha Lipoic Acid 100mg and d-Biotin 150mg
  • Inactive ingredients include cellulose, calcium phosphate, silicon dioxide, and magnesium stearate (vegetable source).
  • Each bottle has 60 capsules

Dosage recommendation:

Take one capsule per day or as recommended by your doctor.

Price/Value

The product is reasonably priced considering that the tablets are made from the stabilized R-form which has better bioavailability, and biotin, a universal antioxidant. One bottle has a supply of capsules that can last you for two months.

Verdict

This option is not only a trusted brand but also a superior supplement. It has enhanced bioavailability, meaning that most of it will be metabolized and availed to the tissues. Also, it is the stabilized form that is more heat and shelf stable.

Pros
  • Bio-enhanced for superior bioavailability in the body
  • Available in small doses
  • Heat and shelf stable
  • Has biotin
  • Suitable for vegetarians
  • Easy to swallow
Cons
  • Can cause stomach discomfort

7. Best Naturals

7. Best Naturals
Best Naturals is a USA-made product made in accordance with GMP standards and in an approved facility. The capsules are highly potent, and each has 600mg of active Alpha Lipoic Acid. This product is free of artificial color, flavor, preservatives and safe from many potential allergens.
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Features/Specifications

  • Made in the USA
  • Processed in an FDA approved facility under GMP standards
  • Each capsule has 600mg of Alpha Lipoic Acid as the active ingredient
  • Inactive ingredients are rice flour, gelatin, vegetable cellulose, vegetable magnesium stearate, and silica
  • Free of preservatives
  • Safe from allergens like egg, soy, gluten, lactose, and fish
  • Each bottle has 240 capsules

Recommended intake:

take one capsule one to two times daily with meals or as prescribed by a healthcare provider.

Price/Value

For 240 capsules, it is unquestionable that the product is reasonably priced. This supply can last for about eight months if you are taking the minimum dosage.

Verdict

For the great price, efficiency, quality, and safety of this product, we are convinced that it will most likely meet your health demands. Moreover, if you have any gluten, soybean, egg protein, fish, peanut or lactose sensitivity, you can take this product comfortably without worrying about an allergic reaction.

Pros
  • Has very many tablets in one bottle
  • High quality and effective
  • Reasonably priced
  • Free of potential allergens
  • Highly potent
Cons
  • Prone to causing heartburn due to the high dose

Difficult to swallow

8. Source Naturals

8. Source Naturals
Source Naturals product is different from most others because it is a timed-release form of Alpha Lipoic Acid. This means that it is slowly absorbed from the digestive tract and gradually released to the tissues for utilization. Therefore, it stays in the body for an extended period, and the effects are felt for a longer period. For this reason, this supplement can be taken in lower doses, even as low as 50mg.
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Features/Specifications

  • Time-release type for extended action
  • Is in tablet form
  • Has both Alpha Lipoic Acid and calcium as the active ingredients
  • Inactive ingredients include microcrystalline cellulose, dibasic calcium phosphate, hydroxypropyl methylcellulose, magnesium stearate and colloidal silicon dioxide,.
  • Each bottle has 120 tablets
  • Each tablet is 300mg in strength

Directions for use:

take two tablets daily. Can be taken with or without food. However, if the tablets cause abdominal discomfort, take with food. The tablets should not be crashed as they are made specially to be absorbed slowly.

Price/Value

Source Naturals product is fairly priced considering that each bottle has 120 tablets that have prolonged effects that are delivered in smaller and safer doses.

Verdict

This is a good product to buy especially if you are dealing with complications of diabetes. Since it has a prolonged effect, it prevents spikes and crashes of blood sugar at a constant rate. In addition, it has calcium as an active ingredient. A study published in PubMed showed that this combination is effective against cancer cell proliferation. Though the study was on mouse cancer models and a clinical trial is still warranted, it is a big plus for this product.

Pros
  • Has a prolonged action
  • Hypoallergenic
  • Low in dosage
  • Minimal side effects
  • Combined with calcium
Cons
  • The tablets are large

9. Simply Nature

9. Simply Nature
Simply Nature's option has both the R-ALA and S-ALA form and is thus maximumly utilized by the body. Each capsule has a strength of 600mg equally divided into the two Alpha Lipoic Acid forms. There are no fillers, binders or artificial additives. The only other substance of the drug is the capsule which is obtained from vegetables.
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Features/Specifications

  • Is in both S-ALA and R-ALA forms
  • Is in a capsule preparation
  • Suitable for vegan and vegetarian diets
  • The only inactive ingredient is the vegetable capsule
  • Each capsule has a strength of 600mg, S-ALA 300mg, and R-ALA 300mg
  • Has enhanced bioavailability
  • No binders, fillers or artificial additives
  • Each bottle has 120 tablets

Directions for dosage:

take one capsule per day or as recommended by your healthcare provider.

Price/Value

Simply Nature supplement is moderately priced but worth considering if you want a product that is high in dosage, has no artificial fillers and is easily utilized by the body tissues.

Verdict

R- Alpha Lipoic Acid is better absorbed and utilized by the body. Simply Nature supplement has both forms, making it superior to other products that only have the S-ALA form. Once the capsules are in the gastrointestinal tract, they are easily taken up by the target tissues and used maximumly for the intended purpose. When buying a nutritional supplement, the expectation is that most of it will be absorbed and used for the right purpose. Simply Nature product meets this expectation, and for this reason it is worth buying.

Pros
  • Both in R -ALA and S-ALA forms
  • Has enhanced bioavailability
  • Free of artificial additives
  • Suitable for vegan/vegetarian diets
  • No fillers and binders
  • Easy to swallow
Cons
  • Highly likely to cause abdominal discomfort

10. NOW Foods

10. NOW Foods
Now Foods product is outstanding because of its combination with Vitamins C and E. Each tablet has 100mg of Alpha Lipoic Acid, 30 International Units of Vitamin E as D-Alpha Tocopheryl Succinate and 250mg of Vitamin C as ascorbic acid. This combination augments its property as a highly powerful antioxidant and significantly improves its absorption.
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Features/Specifications

  • Is a combination of Alpha Lipoic Acid, Vitamins E, and C
  • Is in capsule form
  • Is a powerful antioxidant because of its formulation
  • Suitable for a vegetarian diet
  • Inactive ingredients include rice flour, cellulose, silica, and magnesium stearate (vegetable source).
  • Contains a soy derivative.
  • Free of sugar, salt, yeast, wheat, gluten, milk, egg, shellfish, and preservatives.
  • Each bottle has 120 tablets

Recommended use:

take one to two capsules daily, preferably with food.

Price/Value

Now Foods product is inexpensive and incredibly easy on your budget. The price is unbeatable and yet it is a quality product with remarkable benefits. Moreover, its supply can last you for about four months.

Verdict

As an antioxidant, this product is a very powerful one- the combination of Alpha Lipoic Acid with Vitamins C and E boosts its actions significantly. The best thing about it is that it does not only have these amazing benefits, but the price is also very friendly. For these reasons, the supplement is an excellent product that stands out from the rest.

Pros
  • Combined with Vitamins C and E
  • Powerful metabolic antioxidant
  • In low dosage
  • Minimum side effects
  • Free of artificial additives
  • Easy to swallow
  • Does not have a strong unpleasant smell
  • Affordable
Cons
  • May cause insomnia
  • Contains a soy derivative (some people are sensitive to it)


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