Best Folate Supplements Reviewed In-Depth

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In a Hurry? Editors choice:
1. Solgar – Folate
Test Winner: 1. Solgar – Folate

Folate supplements are an easy and convenient way to make sure your body gets enough folate for many folate-dependent processes in the body, such as cellular division, DNA synthesis, and red blood cell production. Without folate, the body couldn’t repair damaged cells and create new ones when needed.

It’s especially important for people to get enough folate during periods of growth, such as during pregnancy, infancy, and adolescence, and during periods of healing, such as during recovering from an injury or disease. Without adequate folate intake, the body struggles to heal and repair itself and the immune system weakens.

Fortunately, folate supplements promote the bodily functions that depend largely on folate and prevent health complications associated with folate deficiency.

Solgar
  • Solgar
  • 4.9 out of 5
    Our rating
  • Biologically Active
  • Price: See Here
Designs for Health
  • Designs for Health
  • 4.7 out of 5
    Our rating
  • 660 Liquid Servings
  • Price: See Here
Doctor’s Best
  • Doctor’s Best
  • 4.2 out of 5
    Our rating
  • Physician Formulated
  • Price: See Here

Depending on your unique needs, the best folate supplement may vary from user to user. This is why we’ve recommended the top folate supplements that meet a variety of needs.

Many of the folate supplements we’ve recommended are allergen friendly, highly potent, well researched, and appeal to various lifestyles (i.e. vegan, kosher, etc.). We’ve taken these factors into account, so our recommendations serve as the perfect guide to finding your ideal folate supplement.

We found that the best folate supplements contain the biologically active form of folate, which goes by the names L-methylfolate or 5-MTHF. The difference between 5-MTHF and folate is simple – 5-MTHF is ready to be used by the body, making it suitable for people with the methylenetetrahydrofolate reductase (MTHFR) gene mutation that makes it difficult to synthesize folate.

DNA Structure

While 5-MTHF is the most common form of biologically active folate, there are two other forms of folate that are ready to use by the body: Metafolin and Quatrefolic. Metafolin is a proprietary ingredient used in folate supplements with unique benefits – it doesn’t mask vitamin B12 deficiency and is directly usable by the body. Quatrefolic is a fourth-generation form of folate that’s highly stable, active, and water soluble. Both Metafolin and Quatrefolic are suitable for people with the MTHFR gene mutation.

With so many people affected by the MTHFR gene mutation that makes it difficult for the body to absorb folate, biologically active forms of folate are preferred. Liquid folate is also a superior form of folate because it’s absorbed rapidly into the bloodstream. Folate supplements that contain vitamin B12 are also preferable because B vitamins work closely together to prevent B12 deficiency.

For more information on the best folate supplements on the market and everything you need to know about folate supplementation, just keep reading! From active ingredients, quality, recommendation daily dose, and more – we leave no question unanswered.

9 Best Folate Supplements

1. Solgar – Folate

1. Solgar – Folate
The active ingredient in Solgar’s folate supplement is Metafolin, a brand of the biologically active L-methylfolate, making it ideal for people with the MTHFR gene mutation. This is one of the best folate supplements for optimal absorption by the body, making it the Editor’s Choice on our list.
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Ingredients

This product contains 800 mcg of the biologically active form of folate, L-methylfolate, from the brand Metafolin. This folate supplement is allergen friendly, but the tablets contain added ingredients like silica.

Who it’s for

Since this folate utilizes L-methylfolate as its active ingredient, this product is ideal for people with the MTHFR gene mutation, which makes it difficult for the body to metabolize folate. This form of folate is already biologically active and ready for use.

Quality

Solgar has its own Gold Standard of Excellence that every product must meet in addition the multiple tests they run. Their products are created on state-of-the-art equipment that isn’t required but improves the quality of the supplements. Solgar tablets are also easy-to-digest and easy to absorb by the body, as they were one of the first brands to use a water-based coating for their tablets.

Value

Despite being one of the most expensive brands on our list, Solgar products are unmatched in terms of quality.

Brand

With more than 70 years in the health industry, Solgar is a trusted brand of the best folate supplements. They strive to create products that adhere to clean standards. Solgar treats their supplements like food, so all products are made with reverse-osmosis purified water and food-grade equipment.

Pros
  • Promotes heart health
  • Supports nervous system
  • Contains bio-active Metafolin
  • Contains L-methylfolate
  • Allergen friendly
  • Suitable for vegetarians and vegans
  • Non-GMO
  • 100 servings
  • Halal-certified
  • Kosher-certified
  • Food-grade sanitization
Cons
  • Contains added ingredients like silica
  • Slightly more expensive than comparable products

2. Designs for Health – Super Liquid Folate

2. Designs for Health – Super Liquid Folate
Liquid folate supplements are rare, but they can be more effective and easier to absorb. Designs for Health Super Liquid Folate contains 660 servings of both folate and vitamin B12, so this product is a two-in-one. If you’re looking for a long-lasting, easy-to-absorb folate supplement, this may be the best option for you.
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Ingredients

Each drop of this liquid folate supplement contains 400 mcg of folinic acid and 40 mcg of vitamin B12. While this product does not contain the biologically active form of folate, the liquid form will bypass the digestive tract and be immediately absorbed into the bloodstream for rapid absorption.

Who it’s for

The liquid form of supplements is popular among people who struggle to swallow tablets and capsules. The 400 mcg dosage suits the needs of the average adult, and people with higher needs can consume multiple drops of this product. It’s unclear if the liquid form of folate will be absorbed in people with the MTHFR gene mutation, however.

Quality

Designs for Health has a 5-point quality policy: identity, purity, quality, strength, and composition. They have many certifications, and they believe their “Science First” approach makes a difference in the quality and efficacy of their products.

Value

At a glance, this product is more expensive than other folate supplements. However, it’s significantly more affordable per serving at $0.05 per drop. The liquid form of folate is high-quality and it’s long-lasting, making this folate supplement one of the best values.

Brand

Designs for Health adopts a “Science First” approach to their supplements. They are committed to the research and scientific evidence behind their products, which allows them to create nutritional supplements that are industry leaders in efficacy and quality.

Pros
  • Contains 660 servings
  • Contains vitamin B12
  • Contains minimal ingredients
  • Liquid form
  • Allergen friendly
  • Third-party tested
  • Gluten-free
  • Non-GMO
  • GMP certified
  • NSF certified
  • Suitable for vegetarians and vegans
Cons
  • May not be suitable for people with the MTHFR gene mutation
  • More expensive up-front

3. Doctor’s Best – Fully Active Folate 400

3. Doctor’s Best – Fully Active Folate 400
The Doctor’s Best Fully Active Folate 400 is the most affordable option that we reviewed, yet it’s one of the best quality. The folate is sourced from the biologically active form of folate, 5-MTHF from Quatrefolic. This product also contains vitamin C for stability.
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Ingredients

This folate supplement contains 400 mcg of Quatrefolic, a biologically active form of 5-MTHF that’s ready for use in the body. Doctor’s Best also includes vitamin C. This folate supplement contains minimal ingredients and is allergen friendly.

Who it’s for

The average adult requires 400 mcg of folate per day, but pregnant and breastfeeding women need more. This product is ideal for the average person who wants to boost his or her folate levels. Since this folate supplement is biologically active, it’s a preferred option for people with the MTHFR gene mutation.

Quality

All Doctor’s Best products are manufactured in GMP certified facilities for safety and purity. Each product is thoroughly researched according to the latest scientific findings and tested according to their high-quality standards.

Value

Doctor’s Best offers one of the most affordable and accessible folate supplements on the market, making it a great value.

Brand

Like the name implies, Doctor’s Best was founded by a physician. For nearly 30 years, the company has offered science-based supplements that are made primarily with branded ingredients like Quatrefolic.

Pros
  • Affordable option
  • Contains vitamin C
  • Contains Quatrefolic
  • Contains bioavailable 5-MTHF
  • Suitable for vegetarians and vegans
  • Non-GMO
  • Gluten-free
  • Contains minimal ingredients
  • Third-party tested
  • GMP certified facility
  • Supports mood, circulation, and wellbeing
Cons
  • Dose is too low for pregnant and breastfeeding women

4. Pure Encapsulations – Folate

4. Pure Encapsulations – Folate
When Pure Encapsulations say “pure,” they mean it. This brand is one of select few on the market that formulates products that contain just the nutrients and the capsule itself. With this supplement being just the folate and the capsule, it’s a very simple yet potent supplement.
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Ingredients

The Pure Encapsulations folate supplement is one of the few that only contains folate and the capsule itself. Many supplements include filler ingredients and preservatives, but this product is purely folate. The form of folate that is used is highly researched, naturally occurring, and universally metabolized form called Metafolin, which is suitable for people with the MTHFR gene mutation.

Who it’s for

Each 400 mcg serving of this folate supplement by Pure Encapsulations promotes protein utilization, digestive health, nervous system health, and cellular health. This folate supplement also supports the cardiovascular system and the integrity of hair, skin, and nails. The wide variety of benefits makes this supplement a viable option for anyone who wants to promote their overall wellness.

Quality

Top institutions like Stanford University and McLean Harvard Medical School have published more than 30 studies in peer-reviewed medical journals on Pure Encapsulations products. Their products undergo rigorous clinical trials and third-party laboratory testing for safety and efficacy.

Value

Being a high-quality, highly potent, and highly researched product, this supplement is of good value. However, it’s slightly more expensive than comparable products.

Brand

Pure Encapsulations strives to use the purest ingredients possible in its products. They are partnered with many pharmacists and physicians to formulate effective and safe products.

Pros
  • Promotes overall wellness
  • Contains Metafolin
  • Hypoallergenic
  • Non-GMO
  • Gluten-free
  • Free from filler ingredients
  • Highly researched
  • Suitable for vegetarians and vegans
Cons
  • Must be taken with a meal
  • More expensive

5. Jarrow Formulas – Folate & B12

5. Jarrow Formulas – Folate & B12
Jarrow Formulas is a B-complex supplement, which improves the effectiveness and absorption of the folate. Containing added B12 is a plus in our book because folate and vitamin B12 should be taken together anyway, so this supplement is a two-for-one.
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Ingredients

This product is a B-complex supplement containing three B vitamins: Vitamin B6, Vitamin B9 (folate), and Vitamin B12. Since folate can mask symptoms of Vitamin B12 deficiency, it’s recommended to take these B vitamins together. Jarrow Formulas uses a unique version of folate called Quatrefolic, a patented folate salt that is water-soluble, bioavailable, and safe.

Who it’s for

This folate supplement is marketed towards people who want to promote their brain health and amino acid metabolism. If you’re taking amino acid supplements, this product may be a good addition to your supplement regimen.

Quality

This brand invests in research studies to ensure their products are pure, effective, safe, and high-quality. Their facilities include state-of-the-art technology and pharmaceutical grade equipment. All products undergo stringent testing by their quality control teams and third-party laboratories.

Value

The price is comparable to other folate supplements, but this product is likely more researched and higher quality. It also contains two other B vitamins to increase absorption: Vitamins B6 and B12.

Brand

Jarrow Formulas has been manufacturing a variety of health supplements for more than 40 years. With their motto being “Superior Nutrition & Formulation,” their products are highly researched for maximum benefits.

Pros
  • Contains vitamins B6, B9, and B12
  • Third-party tested
  • Follows Good Manufacturing Practices
  • Made using pharmaceutical-grade equipment
  • Lozenges may be easier to consume than capsules or tablets
  • Lemon-flavored lozenges
  • Suitable for vegetarians and vegans
Cons
  • Lozenges contain added ingredients
  • Effectiveness of lozenges is unclear

6. Life Extension – Optimized Folate

6. Life Extension – Optimized Folate
In some cases, a highly potent folate supplement is necessary. For those rare instances, the Life Extension folate supplement is optimized to be up to seven times more bioavailable than comparable products. Not only is this product highly potent and extremely bio-active, it’s also very affordable for the high quality.
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Ingredients

Life Extension Optimized Folate contains 1,000 mcg of L-methylfolate, the biologically active form of folate. This product is allergen friendly and suitable for vegans, but the tablets do contain added ingredients.

Who it’s for

Their active ingredient is up to seven times more bioavailable than folic acid supplements, making this a great fit for people with the MTHFR gene mutation. The high potency of this product is higher than what’s recommended for the average adult, so this product may better suit people who are deficient in folate. Pregnant women who have had preterm birth or babies with birth defects may also benefit from a higher dose of folate.

Quality

Not only does Life Extension take FDA regulations very seriously, they exceed those requirements for top-quality products. They rigorously adhere to Good Manufacturing Practices to ensure potency and purity. Life Extension uses a variety of delivery systems depending on the stability of the raw materials, making their products optimally bioavailable.

Value

Life Extension Optimized Folate is a very affordable folate supplement, but the high potency makes this product an even greater value.

Brand

Life Extension puts quality first – their quality procedures exceed FDA requirements. During the four decades of their existence, Life Extension has unveiled treatment protocols in their own publication. Many of those protocols are now standards in conventional medicine.

Pros
  • Supports cardiovascular and nervous system health
  • Contains bioavailable L-methylfolate
  • High potency
  • 100 servings
  • Non-GMO
  • Suitable for vegetarians and vegans
  • Up to seven times more bioavailable than folic acid supplements
  • GMP certified
Cons
  • Contains added ingredients like silica
  • High potency folate must be taken with vitamin B12

7. Thorne Research – 5-MTHF

7. Thorne Research – 5-MTHF
Thorne Research is passionate about improving the way consumers approach supplements with their highly researched supplements and at-home tests. This highly potent folate supplement is sourced from a biologically active form of folate, 5-MTHF, which is encouraged for people with the MTHFR gene mutation.
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Ingredients

Thorne Research has developed a folate supplement that contains 1,000 mcg of biologically active 5-MTHF. The brand has a “No List” of ingredients their products will never contain, including gluten, dairy, nuts, preservatives, and more. However, the capsules do contain added ingredients.

Who it’s for

High doses of folate are rarely recommended because they can mask symptoms of vitamin B12 deficiency. However, there are certain instances such as in people with folate deficiency or pregnant women experiencing complications wherein potent folate supplements are necessary.

Quality

For more than 30 years, Thorne Research’s motto has been to avoid taking short cuts like their competitors. They source the best ingredients for maximum absorption and have multiple certifications for safety and transparency. All Thorne Research products are manufactured on state-of-the-art equipment and undergo four rounds of testing.

Value

Thorne Research Optimized Folate is slightly more expensive than comparable products, and the length of supply is shorter. However, the brand puts a lot of effort into their formulas, so the product is worth it for the quality.

Brand

Thorne Research manufactures high-quality supplements, but they are also known for their at-home health tests that help people determine their nutritional needs. This brand makes it easy to find the supplements that your body needs.

Pros
  • Supports prenatal health
  • Contains bioavailable 5-MTHF
  • High potency
  • NSF certified
  • GMP certified
  • TGA certified
  • Four rounds of testing
  • Eco-friendly
  • High quality ingredients
  • FDA regulated
  • Cruelty-free
  • Suitable for vegetarians and vegans
Cons
  • More expensive option
  • Contains added ingredients

8. Natural Health Goodies – Methyl Folate

8. Natural Health Goodies – Methyl Folate
With Nature Health Goodies, you’re getting a more natural alternative to purely synthetic supplements. Their formulation of folate is unique and innovative to ensure maximum bioavailability. It’s one of the only folate supplements that combines two different types of folate: methylfolate and Quatrefolic.
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Ingredients

This folate supplement uniquely combines two different sources of folate. 400 mcg comes from methylfolate, a naturally occurring and bioactive source of folate, and 400 mcg comes from Quatrefolic, one of the latest and most innovative sources of folate.

Who it’s for

This folate supplement promotes prenatal development, heart health, and brain health. It’s safe for both pregnant women and people with the MTHFR gene mutation because it contains a biologically active form of folate that requires no conversion once in the body. This supplement exceeds the folate requirements for the average adult and pregnant women, so it appeals to a variety of people with varying folate needs.

Quality

Natural Health Goodies tries to use all-natural ingredients wherever possible. Their facilities comply with strict Good Manufacturing Practices, and all their products are third-party tested for integrity.

Value

This product is slightly more expensive than other folate supplements.

Brand

Natural Health Goodies is a health supplement brand founded by Earth Friendly Goodies, an eco-friendly and sustainable marketplace. They have a passion for doing good for the body and doing good for the earth.

Pros
  • Promotes cognitive and cardiovascular
  • Supports new cell production
  • Contains methylfolate
  • Contains Quatrefolic
  • Allergen friendly
  • Suitable for vegetarians and vegans
  • Made with Good Manufacturing Practices
  • Easy-to-swallow tablets
Cons
  • Contains added ingredients like silica
  • Bottle only lasts for 3 months
  • Slightly more expensive than other folate supplements

9. Pink Stork – Folate

9. Pink Stork – Folate
Pink Stork produces one of the highest quality folate supplements on the market specifically for pregnant women. It’s one of the few products containing Quatrefolic, a biologically active form of folate, making it safe for people with the MTHFR gene mutation. Made by women for women, this is one of the best folate supplements for pregnant women due to its high-quality ingredients and effective formula.
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Ingredients

Pink Stork utilize Quatrefolic as the source of 1,000 mcg of folate in this supplement. It’s an advanced form of folate that improves digestion and increases absorption of the vitamin.

Who it’s for

This folate supplement is designed specifically for pregnant women. The high dosage makes it perfect for women who are expecting a child, so their bodies need extra folate. The biologically active form of folate, Quatrefolic, also makes it safe for people with the MTHFR gene mutation.

Quality

Pink Stork’s range of products are vegan, non-GMO, and free of common allergens. Their facilities follow Current Good Manufacturing Practices as regulated by the FDA, and their products are third-party tested by independent laboratories for quality assurance.

Value

This is slightly more expensive for a 2-month supply of folate, but it’s formulated specifically for pregnant women and is one of the purest forms of folate on the market.

Brand

Pink Stork is a company that creates healthy supplements specifically tailored to the needs of pregnant and lactating women. Made by a mother for other mothers, Pink Stork adopts a “total body” approach to treat causes, not symptoms.

Pros
  • Contains Quatrefolic
  • Contains leucine
  • Suitable for pregnant women
  • Suitable for vegetarians and vegans
  • Follows Good Manufacturing Practices
  • Third-party tested
  • Good source of prenatal nutrition
  • Boosts energy levels
  • Improves digestion and morning sickness
  • Allergen friendly
  • Manages mood
  • Boosts cognition
  • Promotes heart health
Cons
  • Bottle only lasts for 2 months
  • More expensive than other folate supplements


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